Effects of AN-132 and quinidine, antiarrhythmic agents, on plasma digoxin concentrations in rats

Abstract

Abstract The effects of AN-132, 3-(diisopropylaminoethylamino)-2′,6′-dimethylpropionanilide.2H3PO4, on chloroform-induced arrhythmias and plasma digoxin concentrations have been compared with those of quinidine in rats. AN-132 (0.01–3 mg kg−1) administered orally significantly inhibited the incidence of cardiac arrhythmias in a dose-related fashion. A single dose of digoxin (1 mg kg−1) given orally for 7 consecutive days was followed, on day 8, orally by digoxin alone, or together with AN-132 (50, 100 and 200 mg kg−1) or quinidine (25 and 50 mg kg−1). The AUC0-24 and Cmax of plasma digoxin were enhanced significantly by co-administration of quinidine, but not by AN-132.