Affiliation:
1. Department of Pharmacology, School of Medicine, University of Auckland, Private Bag, Auckland, New Zealand
Abstract
Abstract
The KCl-contracted rat aorta is relaxed by labetalol, dilevalol, amosulalol and KF-4317. These relaxations are not reversed by ICI 118,551 at 10−6 M and, therefore, are not due to β-adrenoceptor agonism. At 10−7 M, labetalol, dilevalol, amosulalol and KF-4317 were β2-adrenoceptor antagonists as they inhibited the relaxant responses of rat aorta to procaterol.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference14 articles.
1. Antihypertensive actions of an isomer of labetalol and other vasodilator-beta-adrenoceptor blockers;Baum;Fed. Proc.,1983
2. Antihypertensive and hemodynamic actions of SCH 19927, the R, R isomer of labetalol;Baum;J. Pharmacol. Exp. Ther.,1981
3. The α- and β-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissues;Brittain;Br. J. Pharmacol.,1982
4. Direct vasodilation by labetalol in anaesthetized dogs;Dage;Br. J. Pharmacol.,1980
5. Effects of (+) and (−)-pindolol, mepindolol and bopindolol on the rat isolated aorta;Doggrell;Blood Vessels,1987
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