Presynaptic changes promoted by alloxan diabetes in the cat isolated heart-Reference-Cited by-同舟云学术

Presynaptic changes promoted by alloxan diabetes in the cat isolated heart

Published:1988-05 Issue:5 Volume:40 Page:362-364
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ladosky E M P¹,Fonteles M C²

Affiliation:

1. Departamento de Fisiologia e Farmacologia do Centro de Ciências Biológicas da Universidade Federal de Pernambuco, Brazil

2. Departamento de Fisiologia e Farmacologia do Centro de Ciências da Saúde da Universidade Federal do Ceará, Fortaleza, Ceará, Brazil

Abstract

Abstract Adrenergic presynaptic functions were evaluated in the cat isolated perfused heart preparation. The sympathetic nerve endings were labelled with [3H]noradrenaline ([3H]NA) and the effect of electric neural stimulation was determined in the presence of drugs which inhibit neuronal or extraneuronal uptake, or which antagonize α-adrenoceptors. [3H]NA overflow was measured in control and diabetic cats and was significantly increased by electric neural stimulation on both conditions. Perfusion with 0.1 μM phentolamine increased transmitter overflow in control hearts but failed to do so on organs obtained from alloxan-treated cats. The data provide evidence that in alloxan diabetic cats there is an abnormality of the adrenergic synapse.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/5/362/37546165/j.2042-7158.1988.tb05268.x.pdf

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