The Sorption of Isosorbide Dinitrate to Intravenous Delivery Systems-Reference-Cited by-同舟云学术

The Sorption of Isosorbide Dinitrate to Intravenous Delivery Systems

Published:1988-09 Issue:9 Volume:40 Page:601-604
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

de Muynck C¹,Remon J P¹,Colardyn F²¹

Affiliation:

1. Laboratory of Pharmaceutical Technology, State University of Gent, Harelbekestraat 72, B-9000 Gent

2. Intensive Care Unit, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium

Abstract

Abstract The sorption of isosorbide dinitrate from 0.9% sodium chloride and 10% glucose solutions, by intravenous delivery systems has been investigated under simulated infusion conditions. Isosorbide dinitrate was stable in both 0.9% sodium chloride and 10% glucose solutions. Intravenous fluid containers, burettes, a syringe, infusion sets and end-line filters were evaluated. Glass containers, methacrylate butadiene styrene burettes and polybutadiene giving sets did not sorb isosorbide dinitrate. Neither did polypropylene syringes when a 10% glucose solution was used. The sorption of isosorbide dinitrate to end-line filters was unimportant but there was a significant loss to the PVC tubing used to connect the filter housing to the catheter.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/9/601/37546817/j.2042-7158.1988.tb05317.x.pdf

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