Identification of 15-Hydroperoxyabietic Acid as a Contact Allergen in Portuguese Colophony-Reference-Cited by-同舟云学术

Identification of 15-Hydroperoxyabietic Acid as a Contact Allergen in Portuguese Colophony

Published:1988-01 Issue:1 Volume:40 Page:42-47
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Karlberg Ann-Therése¹,Bohlinder Karin²,Boman Anders¹,Hacksell Uli³,Hermansson JÖrgen²,Jacobsson Sven⁴,Nilsson J Lars G²

Affiliation:

1. Department of Occupational Dermatology, National Institute of Occupational Health and Karolinska Hospital, Stockholm

2. Apoteksbolaget AB, Central Laboratory, S-105 14 Stockholm

3. Department of Organic Pharmaceutical Chemistry, University of Uppsala, S-751 23 Uppsala and

4. ACO Läkemedel AB, Research and Development Department, S-171 03 Solna, Sweden

Abstract

Abstract 15-Hydroperoxyabietic acid (15-HPA) has been isolated from Portuguese colophony of the gum rosin type and identified as its methyl ester. The structure of the compound was elucidated using UV, IR, NMR and mass spectrometry. 15-HPA methyl ester was found to be an elicitor when tested in colophony-sensitized guinea-pigs. The sensitizing capacity was verified in the same species and 15-HPA methyl ester was considered to be a strong allergen. The eliciting potential was also verified in patients with known allergy to colophony. The Portuguese gum rosin investigated contained approximately 1% of 15-HPA. Based on its allergenicity and the amounts isolated, we conclude that 15-HPA is a main contact allergen in Portuguese gum rosin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/1/42/37545615/j.2042-7158.1988.tb05147.x.pdf

Reference27 articles.

1. The Infra-red Spectra of Complex Molecules

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