Repeated treatment with imipramine and amitriptyline reduced the immobility of rats in the swimming test by enhancing dopamine mechanisms in the nucleus accumbens-Reference-Cited by-同舟云学术

Repeated treatment with imipramine and amitriptyline reduced the immobility of rats in the swimming test by enhancing dopamine mechanisms in the nucleus accumbens

Published:1988-02 Issue:2 Volume:40 Page:155-156
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Cervo Luigi¹,Samanin Rosario¹

Affiliation:

1. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 20157 Milan, Italy

Abstract

Abstract Bilateral injections of 1 μg sulpiride in the rat nucleus accumbens antagonized the effect of a seven-day treatment with 20 mg kg−1 day−1 imipramine or amitriptyline in the swimming test. The data suggest that dopamine mechanisms in the limbic regions of the rat brain are involved in the effect of repeated treatment with imipramine and amitriptyline in that test.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/2/155/37545972/j.2042-7158.1988.tb05208.x.pdf

Reference12 articles.

1. Effect of repeated treatment with desipramine in the behavioral “despair” test in rats: Antagonism by “atypical” but not “classical” neuroleptics or antiadrenergic drugs

2. Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test

3. Differential activities of some benzamide derivatives on peripheral and intracerebral administration

4. Effects of antidepressant drugs on different receptors in the brain

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