Action of mefloquine on toad isolated rectus abdominis muscle

Author:

Lee H S1,Go M L2

Affiliation:

1. Departments of Pharmacology, National University of Singapore. Kent Ridge, Republic of Singapore 0511

2. Departments of Pharmacy, National University of Singapore. Kent Ridge, Republic of Singapore 0511

Abstract

Abstract The effects of mefloquine and quinine on acetylcholine-induced contractures of the toad rectus abdominis muscle have been investigated. Both drugs depressed acetylcholine-induced contractures in a dose-related and non-competitive manner. A partial reversal of the block was observed in the presence of 4-aminopyridine(10, 50 μM) and increased Ca2+ content (1.25 ×) of the Ringer solution. In both cases, the mefloquine-induced blockade was more readily reversed than that induced by quinine. Mefloquine and quinine at concentrations greater than 100 and 500 μM, respectively, also elicited a direct contractile response on the muscle. Quantitative differences in their contractile activity have been attributed to the greater lipid solubility and tissue binding affinity of mefloquine.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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