Affiliation:
1. School of Pharmacy, Portsmouth Polytechnic, White Swan Road, Portsmouth PO1 2DT, UK
Abstract
Abstract
The association of free or liposome-entrapped [3H]methotrexate ([3H]MTX) with thioglycollate-elicited macrophages was investigated in-vitro. [14C]Cholesteryl oleate was incorporated into the liposomes as a lipid marker. [3H]MTX association with the macrophages was 5 to 9-fold higher with liposome-entrapped [3H]MTX than with the free drug. Macrophage-liposome association was biphasic, temperature-dependent and saturable at high liposomal lipid concentration. A high liposome cholesterol (CH) content or the presence of 2,4-dinitrophenol or colchicine also reduced macrophage-liposome association.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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