The effect of ciprofibrate on gastric secretion in the rat-Reference-Cited by-同舟云学术

The effect of ciprofibrate on gastric secretion in the rat

Published:1988-07 Issue:7 Volume:40 Page:512-513
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Eason C T¹,Pattison A¹,Howells D D¹,Bonner F W¹

Affiliation:

1. Toxicology Department, Sterling- Winthrop, Research Centre, Alnwick, Northumberland, UK

Abstract

Abstract The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg−1 and following a single intraduodenal dose of 100, 300 and 500 mg kg−1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/7/512/37546773/j.2042-7158.1988.tb05289.x.pdf

Reference12 articles.

1. The results of animals studies with ciprofibrate a new orally effective hypolipidaemic drug;Arnold;Atherosclerosis,1979

2. Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2-receptor blocking drug;Brittain;Br. J. Pharmacol.,1985

3. Drugs affecting lipoprotein disposition in laboratory animals;Dvornik,1980

4. Toxicology studies on omeprazole;Ekman;Scand. J. Gastroenterol.,1985

5. Ciprofibrate in therapy of type II hypercholesterolemia, a double-blind trial;Illingworth;Athersclerosis,1982

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