Sustained anti-adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyflex S) solutions-Reference-Cited by-同舟云学术

Sustained anti-adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyflex S) solutions

Published:1988-07 Issue:7 Volume:40 Page:509-511
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Blenkharn J Ian¹

Affiliation:

1. Department of Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London W12 0HS, UK

Abstract

Abstract Taurolidine (2% w/v) and noxythiolin (1% w/v and 2.5% w/v) solutions inhibit the adherence in-vitro of Escherichia coli and Staphylococcus aureus to human epithelial and fibroblast cells. This effect, demonstrable after 30 min exposure of cells to test drugs, persists after removal of the active compound. Significantly reduced adherence of bacteria is apparent for 5 h after taurolidine treatment and for 6 h after treatment with 2.5% noxythiolin. Anti-adherence activity of taurolidine and noxythiolin may contribute to the observed clinical efficacy of these agents.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/40/7/509/37546724/j.2042-7158.1988.tb05288.x.pdf

Reference17 articles.

1. Comparison of adherence and urine growth rate properties of Staphylococcus saprophyticus and Staphylococcus epidermis;Almeida;Eur. J. Clin. Microbiol.,1984

2. The differential cytotoxicity of antiseptic agents;Blenkharn;J. Pharm. Pharmacol.,1987

3. The antibacterial and anti-endotoxin activity of taurolidine in combination with antibiotics;Blenkharn;Surg. Res. Commun.,1987

4. The in-vitro and in-vivo activity of Taurolin against anaerobic pathogenic organisms;Browne;Surg. Gynecol. Obstet.,1977

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Use of a taurolidine containing antimicrobial wash to reduce cardiac implantable electronic device infection;Europace;2023-10

2. The effect of intraoperative immersion solutions on acellular dermal matrix: Biofilm formation and mechanical property;Journal of Plastic, Reconstructive & Aesthetic Surgery;2023-09

3. Salvage of Cardiac Implantable Electronic Device Pocket Infection with Skin Erosion in Frail 92-Year-Old;Journal of Cardiovascular Development and Disease;2022-03-10

4. Salvage of infected cardiac implantable electronic device with taurolidine—a case report;The Cardiothoracic Surgeon;2022-02-16

5. EDTA and Taurolidine Affect Pseudomonas aeruginosa Virulence In Vitro —Impairment of Secretory Profile and Biofilm Production onto Peritoneal Dialysis Catheters;Microbiology Spectrum;2021-12-22