Characterization of the sphericity of particles by the one plane critical stability

Author:

Chapman S B1,Rowe R C1,Newton J M2

Affiliation:

1. ICI Pharmaceuticals Division, Alderley Park, Macclesfield, SK10 4TG

2. School of Pharmacy, University of London. 29 39 Brunswick Square, London WC1N 1AX. UK

Abstract

Abstract A method has been developed to characterize the roundness of particles in terms of the angle necessary to tilt a plane such that the particles would roll, the ‘one plane critical stability’. The method is based on determination of the centre of gravity of the particle from a digitized image of the coordinates of its outline and computing the angle necessary to incline a plane such that the centre of gravity moves outside the boundary of the particle. The method is particularly applicable to differentiate between the various shapes formed during the production of spherical granules by extrusion/spheronization.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference9 articles.

1. Particle Size Measurement

2. Powder metallurgy review a) Part 1;Beddow;Particle shape analysis.,1976

3. On relating some particle profile characteristics to the profile Fourier coefficients;Beddow;Powder Technol.,1977

4. Preparation of small solid pharmaceutical spheres;Conine;Drug Cosmetic Ind.,1970

5. Technique for the characterisation of shape distributions of powders;Crayton;Powd. Met. Int.,1974

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