Affiliation:
1. Research Division, Allen & Hanburys Limited, Ware, Hertfordshire
Abstract
Abstract
A homologous series of polymethylene-bis-4-aminoquinaldinium salts has been shown to possess marked fungistatic activity against the potential pathogens Candida albicans and Pityrosporum ovale. The peak of antifungal activity against C. albicans occurs at a chain length (CH2)12, whilst against P. ovale the most active member of the series has a chain length (CH2)6. The decamethylene member (dequalinium), shows a potent and rapid fungicidal activity against both yeasts; quantitative data, from experiments involving short periods of drug-yeast contact, indicates that this activity of dequalinium is a function of the concentration of the quaternary compound and of the time of exposure.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
10 articles.
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