A New Analeptic: 5,5-Diethyl-1,3-Oxazin-2,4-Dione (Dioxone): I. Toxicity and Convulsant Activity

Abstract

Abstract Dioxone (5,5-diethyl-1,3-oxaziti-2,4-dione) is a new substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Its convulsant properties have been studied quantitatively in mice and rats. By comparison with the other two analeptics, dioxone shows the highest ratio of lethal to convulsive doses. Dioxone is active orally in mice, rats and dogs. Experiments on spinal cats and rabbits have shown that it does not act on the spinal cord. In the decerebrated animals its effects appear limited and inconsistent. It has a relatively low toxicity, is well tolerated by rats and dogs when administered for up to 6 months either subcutaneously or orally.