Absorption and Elimination of Griseofulvin from the Alimentary Tract of the Rat

Abstract

Abstract A new method is described for determining griseofulvin in the alimentary canal of rats dosed orally with the antibiotic: slightly modified, the method was used for measuring faecal griseofulvin. Attempts have been made to correlate the appearance of griseofulvin in the blood stream with its disappearance from the alimentary canal and to assess how much of a single oral dose is absorbed. Lack of griseofulvin at its main absorption sites in the alimentary tract was not responsible for the decline in blood level 4 hr. after oral dosing, because substantial amounts of unabsorbed antibiotic were then still present. Faecal elimination of griseofulvin, as determined by the new assay, is much greater than reported earlier.