The Anti-Anaphylactic Activity of Ethanolamine and Choline

Author:

Smith W G1

Affiliation:

1. Research Laboratory in Biochemical Pharmacology, Department of Pharmacy, Sunderland Technical College

Abstract

Abstract Ethanolamine, N-methylethanolamine, N-dimethylethanolamine and choline have anti-anaphylactic activity in actively sensitised guinea-pigs. Administered alone their activity is slight, but they considerably potentiate the limited protection afforded by mepyramine. Ethanolamine has been shown to inhibit the release of the slow reacting substance of anaphylaxis in guinea-pig lung subjected to anaphylaxis in vitro.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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