Altered ocular absorption and disposition of sodium cromoglycate upon ion-pair and complex coacervate formation with dodecylbenzyldimethylammonium chloride-Reference-Cited by-同舟云学术

Altered ocular absorption and disposition of sodium cromoglycate upon ion-pair and complex coacervate formation with dodecylbenzyldimethylammonium chloride

Published:1981-09 Issue:1 Volume:33 Page:749-753
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

WILSON C G¹,TOMLINSON E¹²,DAVIS S S¹³,OLEJNIK O¹³

Affiliation:

1. Department of Physiology and Pharmacology, Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH, UK

2. Subfaculty of Pharmacy, University of Amsterdam, Plantage Muidergracht 24, 1018TV Amsterdam, The Netherlands

3. Department of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK

Abstract

Abstract Ion-pair formation between the dianionic drug sodium cromoglycate and dodecylbenzyldimethylammonium chloride has been found to alter the extent and rate of corneal penetration of both large ions upon their coadministration. Additionally, using a complex coacervate of the two large ions as the applied dose form (in which the complex is in equilibrium with the ion pairs), a change in the overall disposition of both large ions to the various components of the eye is observed.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/33/1/749/37771291/j.2042-7158.1981.tb13925.x.pdf

Reference19 articles.

1. Influence of various anions on intestinal disappearance of hexamethonium chloride and pralidoxime chloride in rats

2. THE AQUEOUS SOLUTION BEHAVIOR OF LARGE UNIVALENT IONS. A NEW TYPE OF ION-PAIRING1a

3. Effect of Bile Salts on Partitioning Behavior and Gi Absorption of a Quaternary Ammonium Compound, Isopropamide Iodide

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