Effects of Opioid and α2-Adrenoceptor Agonists on the Isolated Ileum of Morphine-dependent Guinea-pigs During Withdrawal and After Clonidine Treatment-Reference-Cited by-同舟云学术

Effects of Opioid and α2-Adrenoceptor Agonists on the Isolated Ileum of Morphine-dependent Guinea-pigs During Withdrawal and After Clonidine Treatment

Published:1992-02 Issue:2 Volume:44 Page:101-104
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Colado M I¹,Martin M I¹

Affiliation:

1. Institute de Farmacología y Toxicologia, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain

Abstract

Abstract The present study was undertaken to investigate the effect of clonidine administration to opiate-dependent guinea-pigs after morphine withdrawal on subsequent twitch responses of the longitudinal muscle-myenteric plexus preparations to electrical field stimulation. The results indicate that clonidine, administered immediately after morphine removal, causes tolerance to the inhibition exerted by opioid and α2-adrenoceptor agonists on the electrically-evoked twitches. Such a finding suggests that the mechanism of action of clonidine involves not only its well-known effects on locus coeruleus neurons but also that it has specific actions on the myenteric plexus. This work shows the existence of interactions between opioid and α-adrenoceptor on the cholinergic neurons present in the isolated ileum.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/44/2/101/37243648/j.2042-7158.1992.tb03570.x.pdf

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