Bupivacaine kinetic changes during the oestrous cycle in rats

Author:

Bruguerolle Bernard1

Affiliation:

1. Medical Pharmacology Laboratory, Faculty of Medicine of Marseille, Bd J. Moulin, F 13385 Marseille Cedex 5, France

Abstract

Abstract After a single 20 mg kg−1 i.p. dose during pro-oestrus, oestrus or dioestrus, bupivacaine kinetics in rats were not significantly different except for Cmax which was significantly higher during dioestrus.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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3. Modifications de la pharmacocinetique de la theophylline au cours du cycle oestral chez la ratte;Bruguerolle;Pathol. Biol.,1987

4. Influence of the menstrual cycle on the absorption and elimination of d-xylose;Fiset;Clin. Pharmacol. Ther.,1990

5. The influence of age and sex on the metabolism of tiaramide in the rat;Iwasaki;Xenobiot. Metab. Disp.,1986

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