Diuretic Action of the Novel Loop Diuretic Torasemide in the Presence of Angiotensin II or Endothelin-1 in Anaesthetized Dogs

Author:

Uchida Takeshi1,Hayashi Kazutaka1,Kido Hideaki1,Watanabe Masahiro1

Affiliation:

1. Central Research Laboratory, Green Cross Corporation, 2-1180-1 Shodai-Ohtani, Hirakata, Osaka 573, Japan

Abstract

Abstract The effects of torasemide (0·1 and 1 mg kg−1, i.v.) and furosemide (3 mg kg−1) on renal haemodynamics and excretory responses in the presence of angiotensin II and endothelin-1 was examined in anaesthetized dogs. Angiotensin II or endothelin-1 was continuously infused into the renal artery throughout the experiment and a bolus of torasemide or furosemide was injected into the bracheal vein. Continuous intrarenal arterial (i.r.a.) infusion of angiotensin II, at a dose of 5 ng kg−1 min−1, increased renal vascular resistance (RVR) and decreased renal blood flow (RBF) and glomerular filtration rate (GFR), but had no effect on systemic mean arterial pressure (MAP). Urinary excretion of sodium (UNaV) and urine flow (UF) were significantly decreased during angiotensin II infusion. Intravenous injections of torasemide in the presence of angiotensin II caused a dose-dependent increase in UF, UNaV and urinary excretion of potassium (UKV), while a decrease in RVR was accompanied by an increase in RBF. UKV was greater in the furosemide group than in the torasemide group, despite both groups having the same degree of aquaresis and natriuresis. Continuous i.r.a. infusion of endothelin-1, 1·5 ng kg−1 min−1, produced effects similar to those of angiotensin II on renal haemodynamics; however, the onset of action was extremely slow compared with the effects produced by angiotensin II. Endothelin-1 caused a significant decrease in UF, UNaV and UKV only at a later period, despite a relatively early depression of renal haemodynamics. Torasemide and furosemide also produced a sufficient diuretic action in this model. Overall, kaliuresis was greater in the furosemide group than in the torasemide group. The present study demonstrates that torasemide exhibited a significant diuretic action in the angiotensin II- or endothelin-1 -induced renal impairment model, with less kaliuresis than furosemide at a concentration which caused the same degree of natriuresis.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference37 articles.

1. Renin-angiotensin system and acute renal failure;Birbari;Johns Hopkins Med. J.,1976

2. Torasemide, a new potent diuretic; double-blind comparison with furosemide;Broekhuysen;Eur. J. Clin. Pharmacol.,1986

3. Hemodynamic and tubular effect of endothelin and thromboxane in the isolated perfused rat kidney;Ferrario;Eur. J. Pharmacol.,1989

4. Indirect action of angiotensin infusion to inhibit renal tubular sodium reabsorption in dogs;Cannon;Am. J. Physiol.,1966

5. Renal effects of the high ceiling diuretic torasemide in rats and dogs;Ghys;Arzneim.-Forsch.,1985

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3