Affiliation:
1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
Abstract
Abstract
The phencyclidine analogues (±)-α-, (±)-β-, and (+)-α- and (–)-α-4-hydroxy-3-methyl-4-phenyl-l-(1-phenylcyclohexyl)piperidine, all with known relative and absolute stereochemistry, have been prepared, and their analgesic potencies related to corresponding prodines. In contrast to the prodines, the (±)-α-phencyclidine analogue was a more potent analgesic than its diastereoisomer, while in agreement with observations in the prodine series, the 3R, 4S-α-enantiomer displayed substantially greater potency than its mirror image form.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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