Calcium-calmodulin-dependent Activation of Adenylate Cyclase in Prostaglandin-induced Electrically-monitored Intestinal Secretion in the Rat-Reference-Cited by-同舟云学术

Calcium-calmodulin-dependent Activation of Adenylate Cyclase in Prostaglandin-induced Electrically-monitored Intestinal Secretion in the Rat

Published:1992-02 Issue:2 Volume:44 Page:93-96
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Hardcastle J¹,Hardcastle P T¹,Ayton B¹,Chapman J¹,Macneil S²

Affiliation:

1. Department of Biomedical Science, The University, Sheffield S10 2TN, UK

2. Department of Medicine, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK

Abstract

Abstract The calcium-calmodulin antagonist 5-iodo-C8-W7 inhibited the PGE2-induced stimulation of cAMP production by isolated enterocytes from rat small intestine. It also reduced the secretory response of intestinal sheets to PGE2, measured as a rise in short-circuit current. It did not however, inhibit the electrical responses to forskolin and dibutyryl cAMP, nor to acetylcholine, a secretagogue whose effect is not mediated by cAMP. It is concluded that the receptor-mediated activation of adenylate cyclase and the subsequent secretory response are dependent upon calcium-calmodulin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/44/2/93/37243908/j.2042-7158.1992.tb03568.x.pdf

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