Affiliation:
1. United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
Abstract
Abstract
The pharmacokinetics of HI-6 ((4-carboxamidopyridinium (1) methyl)-(2′-hydroxyiminomethyl-pyridinium (1′) methyl) ether dichloride) have been studied in rabbits receiving an intramuscular (50 μg kg−1) or intravenous (12·5 μg kg−1) dose. The plasma concentration-time profile for the intramuscular dose (n = 8) fits a one-compartment open model with first-order absorption and elimination. The absorption half-life was 2 min and maximum concentration (51 μg mL−1) was reached in 9 min. The pharmacokinetics for the intravenous dose (n = 8) was described by a two-compartment open model with first-order distribution and elimination. The apparent volume of distribution was 0·1 Lkg−1. Half-lives of distribution and elimination were 5 and 38 min, respectively. The results indicate HI-6 is rapidly absorbed, distributed and eliminated in rabbits receiving an intramuscular dose.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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