Anti-inflammatory activity of oleanolic acid in rats and mice-Reference-Cited by-同舟云学术

Anti-inflammatory activity of oleanolic acid in rats and mice

Published:1992-05 Issue:5 Volume:44 Page:456-458
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Singh G B¹,Singh Surjeet¹,Bani S¹,Gupta B D²,Banerjee S K²

Affiliation:

1. Pharmacology Department, Regional Research Laboratory, Jammu-Tawi 180 001, India

2. Natural Products Chemistry Division Regional Research Laboratory, Jammu-Tawi 180 001, India

Abstract

Abstract Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg−1 in mice and rats.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/44/5/456/37243914/j.2042-7158.1992.tb03646.x.pdf

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