Affiliation:
1. Department of Pharmacology, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China
Abstract
Abstract
Intestinal eχsorption of salicylic acid, urea and quinidine was measured during the perfusion of the rat intestinal lumen with Tyrode solution. The intestinal clearance (CLi) of the three compounds was measured by dividing the rate of appearance in the intestinal luminal perfusate by the plasma concentration of the compound. Co-administration of theophylline (0 −2 mg h−1) with the test agents increased the CLi of salicylic acid, did not alter the CLi of urea, but decreased the CLi of quinidine. The effect of theophylline on the CLi of quinidine was enhanced with increasing dose. Theophylline was found to increase microclimate-pH at the intestinal surface, but the magnitude of ΔpH alone could not explain the effect of theophylline on the CLi of quinidine. The data, together with previous observations, suggest that the intestinal eχsorption of drugs was affected by the microclimate pH and by the unstirred water layer. Theophylline affects CLi of salicylic acid and quinidine partly by increasing the microclimate pH of the intestine. Theophylline may also affect quinidine CLi by inhibiting the carrier-mediated pathway.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference15 articles.
1. Concentration-dependent exsorption of quinidine in the rat intestine;Bair;J. Pharm. Pharmacol.,1992
2. On the mechanism of intestinal absorption of drugs;Hogben;J. Pharmacol. Exp. Ther.,1959
3. Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis;Huang;J. Pharm. Sci.,1983
4. Effect of altered serum protein binding on the intestinal clearance of 5-disopyramide in rats;Huang;Asia Pac. J. Pharmacol.,1989
5. Comparative drug exsorption in the perfused rat intestine;Huang;J. Pharm. Pharmacol.,1990
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献