Atrial natriuretic peptide inhibits the spontaneous contractions of rabbit isolated ileum

Author:

Blandizzi C1,Agen C1,Natale G1,Del Tacca M1

Affiliation:

1. Institute of Medical Pharmacology, School of Medicine and Dentistry, University of Pisa, Via Roma 55, 1–56126 Pisa, Italy

Abstract

Abstract The present study investigates the effects of atriopeptin II on spontaneous phasic contractions of rabbit isolated ileum. Atriopeptin II caused a significant and concentration-dependent decrease in ileum motor activity. This effect was mimicked by 8-Br-cGMP and it was not affected by pretreatment with tetrodotoxin. Verapamil significantly decreased ileum contractions; however, in the presence of this calcium blocker, atriopeptin II further reduced ileal motility. These findings demonstrate that atriopeptin II depresses the motility of rabbit ileum through a cGMP-dependent mechanism and suggest that neither ileal neural networks nor extracellular calcium are involved in this effect.

Funder

Italian Ministry of University and Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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3. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli;Ballerman;J. Clin. Invest.,1985

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5. Rat intestinal cell atrial natriuretic peptide receptor coupled to guanylate cyclase;Crane;Gastroenterology,1990

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