Brain areas involved in the catecholamine mediated regulation of electroshock seizure intensity

Author:

Stull Richard E1,Jobe Phillip C1,Geiger Paul F1

Affiliation:

1. Division of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe, Louisiana 71203, USA

Abstract

Abstract Selective treatments which alter the catecholamine content of discrete areas of the brain were tested for their effect on electroshock seizure intensity in the rat. The data indicate that depletion of noradrenaline and dopamine in near ventricular areas by the intracerebroventricular administration of the benzoquinolizine, Ro 4–1284, enhances electroshock seizure intensity. The enhancement of seizure produced by systemic Ro 4–1284 was antagonized by the intracerebroventricular injection of noradrenaline or dopamine which do not appear to penetrate more than 1 mm into the brain. Further, pretreatment with systemic iproniazid and l-dopa completely antagonized the increased seizure intensity produced by intracerebroventricular Ro 4–1284 and repleted brain catecholamines in both near and far ventricular areas. Thus, the effects of both noradrenaline and dopamine in attenuating electroshock seizure intensity appear to be exerted principally through periventricular structures.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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