Affiliation:
1. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, London, W.C. 1
Abstract
Abstract
When solutions of adrenaline, noradrenaline, histamine, 5-hydroxy-tryptamine and related amines in trichloroacetic, trifluoroacetic or picric acid are chromatographed in various organic solvent systems, the active material divides into two areas. If a basic amino acid is included in the solution before chromatography, the separation becomes more complete. It is suggested that the second area consists of a loose complex between the amine and the corresponding acid. When solutions of the amines in hydrochloric, acetic or oxalic acid are chromatographed, the active material resides only in one area.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
18 articles.
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