Oxime Therapy in Poisoning by Six Organo-phosphorus Insecticides in the Rat

Abstract

Abstract The effects of two oxime reactivators, PAM and TMB4, on poisoning by six organophosphate indirect cholinesterase inhibitors with different phosphorylating groups have been examined in the rat. Repeated oxime injections were beneficial in poisoning by parathion, parathionmethyl, phenkaptone and, to a lesser extent, diazinon, but ineffective with dimefox and dimethoate. PAM had no additional antidotal value against dimethoate poisoning when given with atropine. The findings are related to expected degrees of irreversibility of cholinesterase inhibition with different phosphorus compounds.