An Investigation into the Action of Bases on Chloroform

Abstract

Abstract The reaction of a number of bases with chloroform has been studied by titration of the liberated halide ion. The results are interpreted in the light of strength of the base, and steric factors. The examination of solutions of strong bases such as piperidine and pyrrolidine in chloroform B.P. indicates that the base reacts with an impurity present. This paper provides additional confirmation, to that obtained by Caws and Foster, of the presence of reactive halogeno-hydrocarbons in this solvent. Methods are also described for assessing the quality of a sample of chloroform B.P., and for preparing chloroform free from these reactive impurities.