The Effect of Substance P on the Peristaltic Reflex When Acting on the Outside of the Isolated Guinea Pig Ileum

Author:

Beleslin D1,Varagić V1

Affiliation:

1. Department of Pharmacology, Medical Faculty, Belgrade, Yugoslavia

Abstract

Abstract Substance P (30–100 units) when acting on the outside of the isolated guinea pig ileum abolished the peristaltic reflex. Small doses (4 units) occasionally potentiated peristalsis. The block produced by high doses could not be overcome by intraluminal injections of 5-HT or substance P itself. The effect of nicotine was reduced or abolished in the presence of high doses of substance P. The high doses can also block the response of the gut to the small doses of the same substance. It is concluded that the blocking effect of substance P takes place between the synapse in the peristaltic reflex arc and the effector cell in the plain muscle.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Search for a physiological role of substance P in gastrointestinal motility;Neuroscience;1985-09

2. Effect of neuropeptides on the efficiency of the peristaltic reflex;Naunyn-Schmiedeberg's Archives of Pharmacology;1979

3. Distribution and Biological Effects of Substance P;Journal of Pharmaceutical Sciences;1966-08

4. Substance P: A Polypeptide of Possible Physiological Significance, Especially Within the Nervous System;International Review of Neurobiology Volume 4;1962

5. Pharmacology of Autonomic Ganglia;Annual Review of Pharmacology;1961-04

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