Affiliation:
1. Smith & Nephew Research Limited, Hunsdon Laboratories, Ware, Herts
Abstract
Abstract
A series of alkyl and aryl esters of 4-aminosalicyclic acid (PAS) has been examined for protective effect in mice infected with Mycobacterium tuberculosis H37Rv, and the PAS blood levels after oral administration to mice, rats and rabbits studied. On the basis of these results, p-tolyl-4-aminosalicylate (p-tolyl PAS) was selected for further examination and has been shown to be of low toxicity in experimental animals and to produce moderately high and sustained PAS blood levels in man.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
1 articles.
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1. Drug Latentiation;Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques;1962