Rheology of pharmaceutical granulations

Author:

Schildcrout Sigmund A1

Affiliation:

1. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana USA

Abstract

Abstract The rheological transformations that take place when granulating fluid is added to pharmaceutical powders have been monitored by means of a laboratory scale (approx. 50 g amounts) torque rheometer. The three formulations studied, based on lactose, sulfadiazine, and benoxaprofen, had common characteristics in that each passed through a granulation peak of maximum torque. In the zone immediately before the peak the granules were growing, while after it the material had properties of a cohesive, viscoelastic mass. Therefore, the rheological state of the material under process is not specified by a single torque reading, but by the rheological history of the granulation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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