Affiliation:
1. Department of Physiology and Pharmacology, Royal College, University of Strathclyde, Glasgow G1 1XW, UK
Abstract
Abstract
This study confirms that exaprolol is a potent β-adrenoceptor antagonist, having a pA2 value of 9·8 for the inhibition of the inotropic and chronotropic responses of guinea-pig isolated atrial preparations to isoprenaline. In the anaesthetized cat, exaprolol blocks both the myocardial stimulatory and vasodilating effects of isoprenaline, suggesting that it is a non-selective antagonist at β-adrenoceptors. Exaprolol also has direct electrophysiological effects on cardiac (Purkinje) tissue, reducing the rate of rise of phase 0 of the action potential. This direct action together with its marked blockade of β-adrenoceptors may explain the drug’s ability to markedly suppress the ischaemic ventricular arrhythmias that follow coronary artery occlusion in anaesthetized rats.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
6 articles.
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