Tropolone antagonism of the l−dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in rat hypothalamus

Abstract

Abstract Tropolone, an inhibitor of catechol O-methyl transferase, largely prevented the increase in SAH: SAMe ratio in rat hypothalamus following l−dopa injection. Tropolone did not prevent but instead enhanced the decrease produced by l−dopa of adrenaline concentration in rat hypothalamus. The results imply that the decrease in hypothalamic adrenaline concentration following l-dopa injection was not caused by the increase in SAH: SAMe ratio.