Affiliation:
1. Department of Hygienic Chemistry, Osaka College of Pharmacy, Matsubara, Osaka 580, Japan
Abstract
Abstract
The inhibitory effects of NN’-diphenyl-p-phenylenediamine (DPPD), sodium diethyldithiocarbamate (SDDC) and 2,6-di-t-butylphenol (DTBP) on the generation of medullary prostaglandin E have been compared. DPPD (1 μm) and SDDC (1 mm) failed to inhibit arachidonic acid-induced stimulation of prostaglandin E synthesis, while DTBP (1 mm) inhibited it. This suggests that DPPD and SDDC inhibit prostaglandin formation by affecting a phospholipase pathway, and the inhibition of prostaglandin generation by DTBP occurs at the cyclooxygenase step.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
1 articles.
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