Affiliation:
1. Department of Microbiology, Dokkyo University School of Medicine, Mibu, Tochigi 321-02, Japan
Abstract
Abstract
We have found that rat hepatoma cells (R-Y121B) retain alkaline phosphatase activity, and that this enzyme activity is increased by cycloheximide. Actinomycin D also increased the enzyme activity. This increase due to actinomycin D was partially inhibited by cycloheximide. The characteristics of alkaline phosphatase of the cells treated or untreated with cycloheximide or actinomycin D were similar to each other; they were heat labile and the enzyme reaction was strongly inhibited by l−homoarginine, but weakly by l−phenylalanine. The increase in alkaline phosphatase activity with cycloheximide has been termed a ‘superactivation’ of alkaline phosphatase.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
6 articles.
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