Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals-Reference-Cited by-同舟云学术

Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals

Published:1984-04 Issue:4 Volume:36 Page:268-269
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bhattacharya S K¹,Pillai C R²,Mathur M¹,Sen P¹

Affiliation:

1. Department of Pharmacology, University College of Medical Sciences, Ring Road, New Delhi−110029 India

2. Biochemistry Division, N.I.C.D., Delhi−110054, India

Abstract

Abstract The effects of chloroquine and some other antimalarials on the immune responses in experimental animals have been examined. Chloroquine and quinine caused significant decrease of serum anti−SRBC haemagglutination titre. Chloroquine lowered the serum IgM level and also reduced plaque−forming cells in the spleen of mice. The delayed−type hypersensitivity responses to SRBC and the passive cutaneous anaphylaxis were also diminished in rats treated with chloroquine. Thus, the immunosuppressant activity of chloroquine may explain its efficacy in various types of immune disorders.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/4/268/37468416/j.2042-7158.1984.tb04366.x.pdf

Reference16 articles.

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