Complexation of tetracylines with metal ions in relation to photosensitization-Reference-Cited by-同舟云学术

Complexation of tetracylines with metal ions in relation to photosensitization

Published:1984-03 Issue:3 Volume:36 Page:153-156
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Riaz M¹,Pilpel N¹²

Affiliation:

1. Department of Pharmacy, Chelsea College, University of London, Manresa Road, London, SW3 6LX, UK

2. Faculty of Pharmacy, University of the Punjab, Lahore, Pakistan

Abstract

Abstract It has been shown by spectroscopy and by a Photosensitive Index method, involving measurements of interfacial tension, that Cu2+ and Ni2+ form 2:1 complexes with oxytetracycline and 1:1 complexes with demethylchlortetracycline, Fe2+, Zn2+, Mg2+ and Ca2+ form weaker 1:1 complexes with both drugs. The possibility is discussed of using metal ions to reduce photosensitization by tetracyclines in-vivo.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/3/153/37468642/j.2042-7158.1984.tb06929.x.pdf

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