The effect of different oils on the absorption of probucol in the rat-Reference-Cited by-同舟云学术

The effect of different oils on the absorption of probucol in the rat

Published:1984-09 Issue:9 Volume:36 Page:641-643
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Palin K J¹,Wilson C G²

Affiliation:

1. Department of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

2. Department of Physiology & Pharmacology, Medical School, Queen’s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH

Abstract

Abstract The effect of oily vehicles on the gastrointestinal absorption of the hypocholesterolaemic agent probucol has been investigated in the rat. The plasma concentration was determined following its administration in arachis oil (peanut oil), Miglyol 812 (fractionated coconut oil) and liquid paraffin. The total absorption of the drug, calculated as the area under the plasma concentration time curve, was significantly greater for the arachis oil formulation than with the other vehicles. The drug was selectively absorbed via the lymphatic system, lymph drug concentrations being highest following co-administration of arachis oil.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/9/641/37469603/j.2042-7158.1984.tb04919.x.pdf

Reference11 articles.

1. Size of Lipoprotein Particles in the Intestinal Lymph of Rats Fed on Corn Oil, Peanut Oil, Rapeseed Oil or Canbra Oil

2. Probucol

3. A Physicochemical Approach to the Intraluminal Phase of Fat Absorption

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