Time-related effects of benzodiazepines on intestinal motility in conscious dogs-Reference-Cited by-同舟云学术

Time-related effects of benzodiazepines on intestinal motility in conscious dogs

Published:1984-02 Issue:2 Volume:36 Page:130-132
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Fargeas M J¹,Fioramonti J¹,Bueno L¹²

Affiliation:

1. Laboratoire de Physiopathologie Digestive, Ecole Nationale Vétërinaire, 23 chemin des Capelles, 31076 Toulouse Cédex

2. Station de Pharmacologie-Toxicologie, I.N.R.A. 180 chemin de Tournefeuille, 31300 Toulouse

Abstract

Abstract The effects of diazepam and GABA on intestinal motility were investigated in fasted dogs fitted with strain-gauge transducers. Injected intravenously at 9.00 and 16.00 h, diazepam (0·5 mg kg−1) affected intestinal motility only during darkness i.e. from 19.00 to 7.00 h. These jejunal motor effects which were mimicked by GABA, (0·3 mg kg−1 i.v.) corresponded to a disruption of the migrating myoelectric complex (MMC) with an increased contractile activity. These results demonstrate that benzodiazepines affect the intestinal motility in dog and suggest that the effects are related to sleep-stages.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/2/130/37468846/j.2042-7158.1984.tb03012.x.pdf

Reference21 articles.

1. The effect of diazepam on human gastric secretion

2. Rate of flow of digesta and electrical activity of the small intestine in dogs and sheep.

3. Central Regulation of Intestinal Motility by Somatostatin and Cholecystokinin Octapeptide

4. Secretory and motor activities at the gastroduodenal junction in dogs

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