Effect of l-dopa on glutamate decarboxylase activity in the hypothalamic and amygdaloid nuclei-Reference-Cited by-同舟云学术

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Effect of l-dopa on glutamate decarboxylase activity in the hypothalamic and amygdaloid nuclei

Published:1984-05 Issue:5 Volume:36 Page:336-337
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Itoh Masatoshi¹,Nohtomi Akito¹,Yufu Nobuo¹,Uchimua Hideyuki²

Affiliation:

1. Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Fukuoka 812

2. Laboratory for Neurochemistry, Hizen National Mental Hospital, Kanzaki, Saga 842-01, Japan

Abstract

Abstract Repeated administration of l-dopa methylester produced a significant increase in glutamate decarboxylase (GAD) activity without pyridoxal-5′-phosphate in the lateral hypothalamic area and medial amygdaloid nucleus. The effect of l-dopa on GAD activity was opposite to that of haloperidol in the lateral hypothalamic area.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/5/336/37468880/j.2042-7158.1984.tb04388.x.pdf

Reference8 articles.

1. KINETICS OF BRAIN GLUTAMATE DECARBOXYLASE. INTERACTIONS WITH GLUTAMATE, PYRIDOXAL 5-PHOSPHATE AND GLUTAMATE-PYRIDOXAL 5-PHOSPHATE SCHIFF BASE

2. Effects of l-DOPA on GABA metabolism in chick brain and retina

3. Regional differences in cofactor saturation of glutamate decarboxylase (GAD) in discrete brain nuclei of the rat

4. L-DOPA: Effect on cerebral pyridoxal phosphate content and coenzyme activity

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