Affiliation:
1. Reckitt and Colman Psychopharmacology Unit, Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Abstract
Abstract
The effects of novel opioid antagonists on the behavioural syndrome induced by electroconvulsive shock (ECS) in rats have been examined and compared with those of the established agent naloxone. A single ECS produced catalepsy and significantly increased tail immersion response times during the 15 min following the seizure. These responses were inhibited by a low dose of naloxone (1 mg kg−1, i.p.) and also by RX8008M (16-methylcyprenorphine; 1 mg kg−1, i.p.) which blocks μ- and δ- but not κ-opioid receptor function. In comparison, the antinociception and catalepsy induced by ECS was not attenuated by the selective δ-receptor antagonist naltrindole (1 mg kg−1, i.p.). These results suggest that ECS-induced antinociception and catalepsy may be mediated by endogenous opioids acting at μ-opioid receptors and are consistent with biochemical studies showing the release of β-endorphin in both animals and man following this procedure.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference29 articles.
1. Evidence for δ-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats;Belenky;Life Sci.,1983
2. Effect of the antagonist 16-methyl cyprenorphine (RX8008M) on opioid-induced changes in urine output in the water-loaded rat;Birch;Br. J. Pharmacol.,1987
3. In-vivo studies with the opioid antagonist, 16-methylcyprenorphine;Birch;J. Pharm. Pharmacol.,1988
4. Effect of electroconvulsive shock on β-endorphin immunoreactivity of rat brain, pituitary gland, and plasma;Dias;Behav. Neural Biol.,1981
5. Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test;Fanselow;Pharmacol. Biochem. Behav.,1989
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