Affiliation:
1. Department of Obstetrics and Gynecology, University of Tübingen, 7400 Tübingen, Germany
Abstract
Abstract
Liposomes produced from phosphatidylcholine and cholesterol and containing Patent Blue V have been injected endolymphatically in the rabbit. The lymph nodes stained dark blue and retained this colour until termination of the experiment after 28 days. No toxic effects were observed histologically. The liposomes were deposited within the macrophages in a fine granular pattern. Because endolymphatic injection of such liposomes produces excellent contrast between retroperitoneal lymph nodes and their surrounding fatty tissue, it can improve both the radicality and the selectivity of lymphonodectomy in oncological surgery.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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