Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs-Reference-Cited by-同舟云学术

Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs

Published:1991-03 Issue:3 Volume:43 Page:204-206
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Neubert Reinhard¹,Fischer Silke¹

Affiliation:

1. Sektion Pharmazie der Martin-Luther-Universität, Halle-Wittenberg, DDR-4010 Halle/Saale, Germany

Abstract

Abstract The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system. The transport of both drugs was markedly enhanced by hexylsalicylate and by salts of fatty acids with a maximum at decanoate. The transport of pholedrine was additionally increased by bile salts such as desoxycholate.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/43/3/204/37240825/j.2042-7158.1991.tb06667.x.pdf

Reference12 articles.

1. Arzneimittelpermeation. 10. Mitteilung: Einfluβ der Diffusionsschichten;Fürst;Pharmazie,1980

2. Pharmakokinetik des Pholedrins;Fürst;Ibid.,1990

3. Bretylium pharmacokinetics and bioavailabilities in man with various doses and modes of administration;Garrett;Biopharm. Drug Disp.,1982

4. The influence of bile salts on the absorption in vitro and in vivo of propranolol;Gasco;J. Pharm. Biomed. Anal.,1984

5. Facilitated transfer of cationic drugs across a lipoidal membrane by oleic acid and lauric acid;Green;Int. J. Pharm.,1987

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