Affiliation:
1. Department of Pharmacokinetics and Drug Metabolism, Institute of Pharmacology, Polish Academy of Sciences, 31–343 Krakow, Poland
Abstract
Abstract
Regional distribution of imipramine, desipramine and specific [3H]desipramine binding sites in the rat brain after acute and chronic treatment of rats with imipramine has been investigated. Both substances were distributed unevenly within rat brain after single and prolonged administration of imipramine. This was partly connected with the regional cerebral blood flow, lipid content in the regions and lipophilicity of the substances investigated. It was also found that the number of specific [3H]desipramine binding sites was different in the various brain areas, and that prolonged administration of imipramine led to a decrease of their number in some of those regions. No correlation was found between the regional cerebral distribution of desipramine and the regional density of specific [3H]desipramine binding sites.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference25 articles.
1. Modulation of neuronal serotonin uptake by a putative endogenous ligand of Imipramine recognition sites;Barbaccia;Proc. Natl. Acad. Sci. USA,1983
2. Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo;Barkai;J. Pharmacol. Exp. Ther.,1984
3. The total fate of drugs: kinetics of distribution, excretion and formation of 14 metabolites in rats treated with imipramine;Bickel;Arch. Int. Pharmacodyn.,1968
4. Localization and characterization of [3H]desmethylimipramine binding sites in rat brain by quantitative autoradiography;Biegon;J. Neurosci.,1983
5. Binding of labelled antidepressant to rat brain tissue;Biegon;Biochem. Pharmacol.,1979
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献