Anti-acetylcholinesterase activity of some stereoisomeric aminobornanes-Reference-Cited by-同舟云学术

Anti-acetylcholinesterase activity of some stereoisomeric aminobornanes

Published:1971-07 Issue:7 Volume:23 Page:528-533
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

BECKETT A H¹,LAN NGIAM TONG¹,KHOKHAR ABDUL Q¹

Affiliation:

1. Department of Pharmacy, Chelsea College, University of London, S.W.3, UK

Abstract

Abstract Bornyl analogues of choline and acetylcholine with eclipsed cis- and trans-configurations displayed low inhibitory activity towards acetylcholinesterase catalysed hydrolysis of acetylcholine; cis-isomers were slightly better inhibitors than their trans-counterparts. (+)-Bornan-2-one-3-endo-yltrimethylammonium bromide with its oxygen atom and the quaternary ammonium group fixed rigidly in the gauche configuration is much more potent inhibitor than its enantiomorph.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/23/7/528/37630059/j.2042-7158.1971.tb08702.x.pdf

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4. Steric influence on the chemical reactions and NMR spectra of 2,3-disubstituted bornanes

5. Aspects of the Chemical Mechanism of Complex Formation between Acetylcholinesterase and Acetylcholine-Related Compounds1a,b

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1. Biochemical Characterization of the Muscarinic Receptors;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22

2. Cholinergic Agonists;The Steric Factor in Medicinal Chemistry;1993

3. Muscarinic Receptors in the Central Nervous System;International Review of Neurobiology;1984

4. Analogs of 3-quinuclidinyl benzilate;Journal of Medicinal Chemistry;1982-09

5. Struktur- und Konformations-Wirkungs-Beziehungen heterocyclischer Acetylcholinanaloga, 11. Mitt. Acetylcholinesterase- und Base-katalysierte Hydrolyse von isomeren 3-Acetoxypiperidin- und 3-Acetoxythiacyclohexan-Derivaten;Archiv der Pharmazie;1980