The drug release characteristics of various rectal suppositories as determined by specific ion electrodes

Author:

THOMAS W H1,MCCORMACK R1

Affiliation:

1. Pharmacy Department, University of Otago, Dunedin, New Zealand

Abstract

Abstract Suppositories containing sodium phenobarbitone (200 mg) were manufactured with the following bases; cocoa butter, cocoa butter plus beeswax, Dehydag and polyethylene glycols. The release of sodium ions through a dialysis membrane was conveniently measured with a sodium-specific ion electrode. The method facilitates evaluation and comparison of suppository bases and allows continuous monitoring of the release of active ingredient.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference12 articles.

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1. LORNOXICAM SUPPOSITORIES: IN-VITRO FORMULATION AND IN-VIVO EVALUATION;International journal of pharmaceutical sciences and research;2013-11-01

2. Sustained Release of Diclofenac from Polymer-Containing Suppository and the Mechanism Involved;Drug Development and Industrial Pharmacy;2000-01

3. Rectal absorption and mucosal irritation of rectal gels containing buprenorphine hydrochloride prepared with water-soluble dietary fibers, xanthan gum and locust bean gum;Journal of Controlled Release;1996-01

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