Affiliation:
1. Pharmacological Research Laboratory, Chinoin Pharmaceutical and Chemical Works, Budapest, Hungary
Abstract
Abstract
Rats with myocardial infarcts, sham operated and control animals were treated with methoxyethyl mercury chloride (MEMC) intra-peritoneally or with mercamphamide intravenously or intra-peritoneally and the mercury content in the hearts determined spectrophotometrically with dithizone after various time intervals. After MEMC treatment there was no difference between the amounts of mercury found in the hearts of rats with myocardial infarcts and controls. After injection of mercamphamide, mercury was taken up by hearts of rats with myocardial infarcts while those of sham operated and control animals remained free of mercury. Optimal results were yielded by 1 h experiments made within the first 24 postoperative hours. The selective uptake of mercury from organo-mercurials is much dependent on the organic part of the molecule present in the given individual compound.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
2 articles.
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