The correlation between the in vitro and in vivo availability of salicylic acid for membrane transfer from polysorbate 20 solutions-Reference-Cited by-同舟云学术

The correlation between the in vitro and in vivo availability of salicylic acid for membrane transfer from polysorbate 20 solutions

Published:1974-01 Issue:1 Volume:26 Page:34-38
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Collett J H¹,Withington R¹,Cox B²

Affiliation:

1. Department of Pharmacy, University of Manchester, Manchester M13 9PL, UK

2. Department of Pharmacology, University of Manchester, Manchester M13 9PL, UK

Abstract

Abstract The presence of 1·0% w/v polysorbate 20 in solutions of salicylic acid reduces the absorption of the drug from the rat stomach. This effect is the resultant of two opposing effects of polysorbate 20 on salicylic acid absorption. Firstly, the surfactant reduces salicylic acid absorption by solubilization and secondly the surfactant tends to enhance salicylic acid absorption by an alternate unidentified effect. Knowing the magnitude of the absorption-enhancing effect the overall effect on salicylic acid absorption can be calculated using equations that describe the availability of salicylic acid for transfer across a Cellophane membrane from polysorbate solutions.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/26/1/34/37633088/j.2042-7158.1974.tb12816.x.pdf

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