Metabolism of isoprenaline in the intestine-Reference-Cited by-同舟云学术

Metabolism of isoprenaline in the intestine

Published:1974-04 Issue:4 Volume:26 Page:265-267
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

George C F¹,Blackwell E W¹,Davies D S¹

Affiliation:

1. MRC Clinical Pharmacology Research Group, Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W.12, UK

Abstract

Abstract A method for the study of drug metabolism in isolated canine gut loops is described. This technique has been used to study the conjugation of isoprenaline with ethereal sulphate. After intraluminal injection of tritiated isoprenaline only 3·6% of the radioactivity in venous effluent appeared as free isoprenaline, and 68·0% as a sulphate conjugate. After pretreatment with salicylamide the proportion of free isoprenaline rose to 73·7% and only 3·3% was accounted for as sulphate conjugate. The significance of these findings is discussed in relation to a possible source of drug interaction.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/26/4/265/37633237/j.2042-7158.1974.tb09268.x.pdf

Reference11 articles.

1. On the Occurrence of Phenol and Steroid Sulphokinases in the Human Gastrointestinal Tract

2. A Standardized Isoproterenol Sensitivity Test

3. Metabolism of isoprenaline in dog and man

4. Intravenously Administered Isoproterenol Sulfate Dose-Response Curves in Man

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